Chromatography Forum

Hi everybody,

I haven’t got electronic references and if I should find some litterateur for you I’ll have to visit my attic and spend sometime in it
You should think “densityâ€

No Danko, I didn´t say that "your solids" are more soluble in ice than in liquid under the same temp, but at higher pressure. I asked, because of my gut feeling and limited experience which tell me that the solubility should normally be higher in that liquid.
Your link seems to indicate that the downturn of the solubiliy product is contrary to theory (laws of physics)?
The solubility temperature relationship is also very complex, exothermic substances can have a lower solubility at higher temps (Le Chatelier´s principle).

Now, which law of physics states that lower solubility lowers the number of equilibria (what equilibria?), and: I don´t know what that would mean.

Hans,

Although I didn't describe it appropriately, I was talking about the frictional heating caused by flow through a packed bed (i.e. power = F DP) where F: flow rate and DP: pressure drop...

Hans, you are a very angry young man, but it’s OK

Hans wrote:

The solubility temperature relationship is also very complex, exothermic substances can have a lower solubility at higher temps (Le Chatelier´s principle).

Actually I wasn’t thinking of thermodynamics (the velocity of molecules as a consequence of the elevated temperature) but the solvent’s density which decreases with temperature increase (please read my post again).

Hans wrote:

(what equilibria?)

The partitioning of a solute between two phases. A basic principle of chromatography!

Finally, I found some more reading about high pressure and proteins:

http://www.sciencedirect.com/science?_o ... a99d69f99e

Most importantly - as I said previously – I just wanted to introduce another point of view – that’s all.

Unfortunately, I haven’t got the time for more teasing.

Have a nice week

Kostas, .... got it.

Danko, from an old man who would like to introduce the point of view that it´s time to end this shifting conjecture.