Chromatography Forum

It seems that it can be done after all:

http://pubs.rsc.org/en/Content/ArticleL ... ivAbstract

First hit on google. Free full text into the bargain. Let us know how it goes.

Peter

Possible, but not an off the shelf instrument by any means.

No indeed, does an off the shelf SFC-MS instrument even exist ?

Peter

Agilent claim the 1260 Infinity SFC system interfaces to 6100 (SQ), 6200 (TOF), 6400 (QTOF), and 6500 (QQQ) series LC/MS systems if you want an out of box system.

Interface of SFC to MS was a driving force for SFC development. The old LC/MS systems used a moving belt interface and getting solvents to evaporate off leaving the compounds of interest was tough , let alone buffers. Using CO2 based SFC solvents with modifiers worked much better

Interesting bit of history, thanks.

Peter