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Posted: Thu Jun 09, 2005 6:53 pm
by John
Maybe the salt in your aqueous MP or sample solvent is precipitating out in your IPA rinse. Suggest a rinse similar in organic composition to your MP (no solutes of course). We use 5% MeOH in water for all our systems.
JW
Posted: Fri Jun 10, 2005 12:43 am
by syx
I have made a conclusion:
Before we decide to choose washing/rinsing solution we must know the solubility of active substance(s) and components of diluent used (buffer).
Posted: Fri Jun 10, 2005 7:56 pm
by Mark Tracy
If you really want to blame the autosampler, take it out and replace it temporarily with a manual injector. See if the problem persists.