Chromatography Forum

The methylene chloride helps to ensure that any less polar compounds are stripped from the source parts. You can try abreviated cleaning procedures, but you need to be sure that this abreviated cleaning works for all of the sample types run on the instrument. If the instrument is a "general use" type of instrument, you have no idea what the next sample will be or what the other users' samples left in the ion source. An abreviated cleaning procedure may be more appropriate on an instrument that runs a particular type of sample.

Blow off parts with canned air if desired then air dry for 10 minutes. Done.

I'd be inclined to skip the canned air - propellants vary and you might end up contaminating your source. You could use zero air if you want to blow dry your source but a quick bake in the oven seems just as easy to me.