USP <467> on Agilent G1888

[GregK]

Well, as it turns out, part (most?) of my problem could be due to a leak. I was frustrated with getting little to no peaks, so I ran the built in leak test. It loses pressure on the vial when the He supply is turned off. I have a call into Agilent now (we have a service contract).

Hopefully, when that is fixed, everything else will be as well.

[Peter Apps]

Hi Greg

I had a G1888 that would not hold vial pressure - there was a sliver of brass swarf across the seat of one of the solenoid valves.

Peter

[chromatographer1]

Peter,

Don't bother offering to give manufacturers a better design. Tried that once and no one was interested.

Why? Their reasons:

It wasn't invent here. (in other words, if we can't invent it it can't be good, or, we don't want to pay someone for something we have to defend as intellectual property)

What we have is good enough. In addition, Perkin ELmer is not defending their old patent on sample loop design so we can copy it for free and it is good enough.

Nobody wants something better or they would have been knocking on our door asking for something else, so how can we justify the cost of the research?

As I noted in my paper in ANALYTICAL CHEMISTRY back in 1997 a complete injection of the vial's headspace is the optimum design to maximize getting the sample onto the column. Nobody wants to go there. The trap and purge HS is an improvement but there is always the issue of variability of the trap as it ages and as it becomes contaminated with use.

Greg,

What is the melting point of your API ?

best wishes,

Rodney George

[Peter Apps]

Peter,

Don't bother offering to give manufacturers a better design. Tried that once and no one was interested.

Rodney George

And they can always just buy someone else's and stick their name on the front.

In principal I never give away anything that someone else is going to make money out of

Peter