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OPA or dansyl related derivatives, are they ok for mass spec

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

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OPA or dansyl related derivatives, are they ok for mass spec

avatar
Jasmine
I intend to set up an LCMS method for drugs that belong to the primary and secondary amine groups, thought of using OPA or dansyl derivatization. Are they compatible with LCMS? If not, can you suggest any other derivatizing agents? Thanks for any help.

avatar
DrPAP
Anal. Chem. 1994, 66, 1302-1315
Chemical Derivatization for Electrospray Ionization Mass
Spectrometry. 1 . Alkyl Halides, Alcohols, Phenols, Thiols,
and Amines
J. Martin E. Quirke, Christopher L. Adams, and Gary J. Van Berkel.
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