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how can i retened polar compounds in RPLC like hcl salts

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how can i retened polar compounds in RPLC like hcl salts

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tirajesh
here i am facing problem with temozolamide Impurities one of the impurity is very polar (dacarbazole impurity) it is in usp, we are following usp method but is not retaining it RT is 2.0 pls give solution for this

Re: how can i retened polar compounds in RPLC like hcl salts

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carls
please post the separation conditions you are using
A. Carl Sanchez
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