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DETECTION LIMIT ON LCMS

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

2 posts Page 1 of 1
Hi,

I recently started working on the LCMS, and I have wondering what is most reliable way to determine the LOD and LOQ for my analyte. Using my calibration curve (standard deviation of the intercept method) gives really high values for the LOD and LOQ. Is there any other acceptable way of doing this apart from S/N? Thank you.
Hi Folarin,

sure there is a different way. Have a look: https://www.agilent.com/cs/library/tech ... 7651EN.pdf
2 posts Page 1 of 1

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