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Simplex optimization

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

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Simplex optimization

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Kimico
Hello,

I was wondering if anybody has information as to how to perform simplex optimization. I was looking for articles that describe a step by step aproach to optimize a method by this technique. Thank you.

MO

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JGK
http://www.grabitech.se/algorithm.htm

http://en.wikipedia.org/wiki/Simplex_algorithm

http://www.chem.uoa.gr/applets/appletsi ... mplex2.htm
Good judgment comes from bad experience, and a lot of that comes from bad judgment.
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