residual Micro 90 surfactant quantitation

[mbreslav]

Any suggestions on chromatographic method development for quantitation of this residual surfactant that does not have any chromophors?

[tom jupille]

The manufacturer's web site describes Micro 90 as a "unique formulation of chelants, ionic, and non-ionic ingredients", and the MSDS doesn't give much more information (http://www.ipcol.com/pdfs/M-90_msds.pdf). I'd contact the manufacturer and ask them for suggestions. Failing useful information from them, the "usual suspects" (RI, ELSD) come to mind, but they tend to have limited sensitivity.

[Consumer Products Guy]

On this site http://www.coleparmer.com/Catalog/produ ... ku=1810010
near the bottom, there's a link to the MSDS, which shows in section 2 (Composition) two benzenesulfonic acid components (at less than 20% each) in the formula. A mixture like that also brings up the question: which component(s) to assay for? In other words, have fun with your QA Department !

[rhaefe]

Micro 90 contains:

Water
tetra sodium EDTA [CAS#64-02-8]
xylene sulfonic acid ammonium salt [CAS#26447-10-9]
benzene sulfonic acid, triethanolamine salt [CAS#27323-41-7]
Linear Undecyl alcohol ethoxylates [CAS#34398-01-1]

Here is some info on validation:
Cleaning Validation
International Products Corporation offers a full-line of safe, powerful, aqueous-based
cleaners designed for critical cleaning. LF2100® Liquid Low-Foam Cleaner, Micro-
90® Concentrated Cleaning Solution, Surface-Cleanse/930® Concentrated Neutral
Cleaner, and Zymit® Low-Foam Enzyme Cleaner can all be validated to meet the
most rigorous specifications for surface cleanliness.
We can provide you with the following methods for testing rinse water to determine if
parts and equipment have been rinsed sufficiently:
1. Methylene Blue/Rinse Water Test* (LF2100 and Micro-90)
2. Conductivity of Rinse Water Test* (LF2100, Micro-90, and Zymit)
3. Foam Test (Micro-90 and Surface-Cleanse/930)
4. Cloud Point Test (Surface-Cleanse/930)
If your critical cleaning process requires a quantitative test method, e.g. to meet FDA
criteria, we can offer assistance on the following methods:
1. UV-Visible Spectrophotometer
2. Total Organic Carbon (TOC)
3. Fourier-Transform Infrared (FTIR)
4. High Performance Liquid Chromatography (HPLC)
Our technical staff would like to help you improve your cleaning process, so please
contact us for assistance.