Advertisement

Anyone have any tips on optimizing ECD equilibration?

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

2 posts Page 1 of 1
Does anyone have any tips on how best to equilibrate an electrochemical detector? (In general?)
Advice from an experienced chromatographer: zap the dual channel analytical cell with +700mV on both E1 and E2 channels for one minute - then place the electrodes on their prescribed settings and await equilibration. He said it would decrease equilibration time and enhance sensitivity.

I just tried this today and can say that this actually worked and it decreased the very-long time it usually takes to equilibrate (I am using an old ECD).

Anyone else have any other tricks to share?
2 posts Page 1 of 1

Who is online

In total there are 26 users online :: 2 registered, 0 hidden and 24 guests (based on users active over the past 5 minutes)
Most users ever online was 4374 on Fri Oct 03, 2025 12:41 am

Users browsing this forum: John Guajardo, Semrush [Bot] and 24 guests

Latest Blog Posts from Separation Science

Separation Science offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for users of liquid chromatography, gas chromatography, mass spectrometry, sample preparation and related analytical techniques.

Subscribe to our eNewsletter with daily, weekly or monthly updates: Food & Beverage, Environmental, (Bio)Pharmaceutical, Bioclinical, Liquid Chromatography, Gas Chromatography and Mass Spectrometry.

Liquid Chromatography

Gas Chromatography

Mass Spectrometry