Compare two different analytical methods

[nbellora]

Hi at all,
i have made two different methods (one with Helium and the other with Hydrogen), i have calibration curves with a good R2 and i quantify the same compounds in both. My problem is that tha compounds quantification its's different in the two methods, but the calibration curve are good.
I don't know how to compare statistically the two methods.

suggestions?

thanks

[dap]

General answer: Fisher's F-test & Student's t-test.

[larkl]

HIghly recommend this text.

https://www.amazon.com/Practical-Statis ... 0442209738

[James_Ball]

Hi at all,
i have made two different methods (one with Helium and the other with Hydrogen), i have calibration curves with a good R2 and i quantify the same compounds in both. My problem is that tha compounds quantification its's different in the two methods, but the calibration curve are good.
I don't know how to compare statistically the two methods.

suggestions?

thanks

Are you saying unknown samples are giving different results or the calibration standards have different results when quantified against the curve?

Is there 1% difference or 20% difference between the Helium and Hydrogen results?

[nbellora]

The calibration curve in both it's good (R2 and accuracy are perfect). But the samples are different from 1% for triacetin and 20% for phenol.
I don't know if it is due to a different sensitivity of the two method.
I want to calculate LOD and LOQ of two methods and maybe made a sample with spike.