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choice of QC's concentrations

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choice of QC's concentrations

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dipols
How should the concentrations for QC samples be chosen? Is it ok if they are identical with calibrator concentrations? All I could find on this topic from FDA was that low QC must be within 3x from LLOQ.
I see that in literature typically QC's concentrations are different from calibrators. What's the rationale behind that?

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tom jupille
Site Admin
I don't think it matters much. Take the attitude that "everything that is not forbidden is permitted". :wink:
-- Tom Jupille
LC Resources / Separation Science Associates
tjupille@lcresources.com
+ 1 (925) 297-5374
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