chromsword

[ramiaqu]

hi

iam looking for trail version (demo) for chromsword the newest version. please any one can help me?

thank you

[tom jupille]

I couldn't find any download links, but the program is sold in Europe by Merck Darmstadt and by Agilent, so you might try contact a sales representative from either of those companies.

[gemm]

you might try to contact the author directly:

Dr. S. Galushko, galushko@chromsword.de

http://www.chromsword.de/13799.html

[ramiaqu]

i have demo for chromsword 2.0 but i have some problems if any body can help me:

1- it contain specific atom we can use in the drawing of the drug struture;my drug contain Co atom which is not included

2- in all the method we get from Chromsowrd the mobile phase not contain any buffer always water, since most of the method in the Pharmacopeas must contain buffer.

any one can help me

[tom jupille]

any one can help me

Yes, try DryLab instead

I'm somewhat biased, since I spend many years working with DryLab. With that "truth in advertising" statement out of the way:

1- it contain specific atom we can use in the drawing of the drug struture;my drug contain Co atom which is not included

I believe the structure-retention predictions from ChromSword are based on reversed-phase chromatography and covalently-bonded molecules. If you have Co in your molecule it is probably either complexed or ionically bound, so ChromSword's models would not be applicable. In any case, my experience has been that ChromSword's "empirical" models (where you calibrate the model with actual retention data) are more accurate.

2- in all the method we get from Chromsowrd the mobile phase not contain any buffer always water, since most of the method in the Pharmacopeas must contain buffer.

It doesn't matter. In any of the modeling programs for reversed-phase (ChromSword, DryLab, ACD, Osiris), the detailed composition of the aqueous part of the mobile phase is irrelevant (i.e., it is assumed to be invariant) as long as you are modeling other parameters (%B, temperature, etc.).