HPLC with ICP-MS

[NazarF]

Good day,

I am wondering if someone can share experience with connecting HPLC to ICP-MS for chromium speciation in samples?

We are using ELAN DRC II and Agilent 1100.

Thanks,

[Gerhard Kratz]

Several years ago the company Knauer, www.knauer.net, has constructed an injection system for ICP in cooperation with university Dortmund.
The professor run several applications combining HPLC with ICP-MS.
Maybe they still can provide you with some literature. Good luck

[jerole]

Hi,

Connecting the HPLC to an ICP-MS is pretty straightforward. Just connect the exit of the column to the sample uptake tubing of the ICP-MS (which should not be connected to your ICP-MS peripump). Take into account that your flow might be higher than your usual sample uptake, therefore set your ICP-MS peripump speed high enough to assure good draining.

J

[James_Ball]

Hi,

Connecting the HPLC to an ICP-MS is pretty straightforward. Just connect the exit of the column to the sample uptake tubing of the ICP-MS (which should not be connected to your ICP-MS peripump). Take into account that your flow might be higher than your usual sample uptake, therefore set your ICP-MS peripump speed high enough to assure good draining.

J

Another way to handle the high flow is to put a Tee fitting between the HPLC outlet and the peripump on the ICP-MS. The ICP peripump will pull in what is needed and the rest will split off to waste.