Assay method for glibenclamide/metformin

[bshyamb]

hi
Even i want to know to develop a method for glibenclamide and metformin hcl in a gliben/met tablet.

unfortunately the post Assay method for glibenclamide/metformin [August 20, 2004] is locked. moreover, there is no reply posted. So i want to reopen this topic to get help.

Please suggest me a method development for extraction of metformin/glibenclamide from human plasma. Also lemme know its Cmax, HPLC method etc.

[AA]

Time to make a trip to the library.

The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma

AbuRuz S

JOURNAL OF CHROMATOGRAPHY B 2005, 817(2) Page: 277-286

[bshyamb]

i did check out JOURNAL OF CHROMATOGRAPHY B 2005, 817(2) Page: 277-286
but i am unable to access the full article because it charges me $30 for it.

if u already have it, can u plz put it in this post or forward me? i will be indebted to you for ur favor.

[AA]

Copyright laws prevent me from sending you this article. You have a couple of choices.

1-Pay the $30
2-Write the author and ask for a copy, most authors will provide one for free.
3-Go to the library with a pad and pencil and write down all of the method detalis.

[HW Mueller]

Hopefully it´s not Germany that has such copyright laws, because..... ah I better not say.
Also, before the internet any university library in Germany send anybody a copy of any of their journals´ articles for 10 Pfennig a page.

[amaryl]

i did check out JOURNAL OF CHROMATOGRAPHY B 2005, 817(2) Page: 277-286
but i am unable to access the full article because it charges me $30 for it.

if u already have it, can u plz put it in this post or forward me? i will be indebted to you for ur favor.

Hello Bshyamb,

Where are you located in India? You may get access to this journal easily at National Medical Library, located adjacent to AIIMS and can get a photostat copy of the article for your further reference.

Regards,

Amaryl.

[AA]

I do not want to be labled as the bad guy here but consider this.

In the US (and many other countries) a copyright gives the owner the exclusive right to reproduce, distribute, perform, display, or license his work.

Since I do not own this work (only the author and publisher are owners) I can not send it out to anyone. Making a photocopy at the library is a violation of that copyright in the US.

If the laws in your countries are different, go ahead, copy away.

If you have ever had your IP stolen and used by others without proper recognition (or payment in some cases) you too might be a little more sensitive to this issue.

[SIELC_Tech]

Amaryl,

You can try to contact one of the authors and request a copy. From my experience this works every time.

I am not an attorney but every department in pharma industry is making copies on thousand articles a year at request of their scientists and a lot of times this copies are circulated in the department. I am not sure that this is considered as Copyright violation, because somebody would be after pharma years ago.

Regards,

Vlad

[amaryl]

Amaryl,

You can try to contact one of the authors and request a copy. From my experience this works every time.

I am not an attorney but every department in pharma industry is making copies on thousand articles a year at request of their scientists and a lot of times this copies are circulated in the department. I am not sure that this is considered as Copyright violation, because somebody would be after pharma years ago.

Regards,

Vlad

Thanx Vlad for your concern but I don't need this copy ! I would have even tried contacting author at 1st stance if it had been my situation.

Well in India its a practice. We can get copies of research work...n here at NML it will juzt cost him 3 rupees if they make some 8-9 pages pretty cheap then buying for 30 $. Library is meant for access to articles.

I don't think its a violation...because research has to start from something to lead to others . Come on its no offense but would look more good if authors distribute copies on request.

Regards,

Amaryl.

I made a century to my posts...with this post !

[amaryl]

I do not want to be labled as the bad guy here but consider this.

In the US (and many other countries) a copyright gives the owner the exclusive right to reproduce, distribute, perform, display, or license his work.

Since I do not own this work (only the author and publisher are owners) I can not send it out to anyone. Making a photocopy at the library is a violation of that copyright in the US.

If the laws in your countries are different, go ahead, copy away.

If you have ever had your IP stolen and used by others without proper recognition (or payment in some cases) you too might be a little more sensitive to this issue.

well I don't know much about copyrights...but licensing this work means they are the owners of developed method and can even earn money if they give this license to someone ...wow a way to earn money !

To my knowledge once the work is in public domain they don't own a license...juzt like patents a copyright should work.

Regards,

Amaryl.

[AA]

You are quite wrong, once published, the work is not public domain. Would you consider a novel or a textbook to be public domain after it is printed?

[HW Mueller]

AA, nobody is trying to label you a "bad guy", apparently nobody thinks that you are trying to label us the bad guys either. For my case I am just astonished at your interpretation. Libraries usually pay considerably more for a journal than individuals, probably to compensate for people being allowed to go there and read articles in their journals. There is no limit to how many people read an article at a library. Now I knew nobody that ever assumed that one is not allowed to make Zerox type copies in libraries for individual use. Who makes this copy for you should be immaterial. Is there something like the reasonabliness of laws and/or their interpretation?

Also, authors can get a huge number of copies for their articles (even though they are not the copyright holders) for incomparibly less than $30 a copy ..............
Why one has to pay ~9 to 30+ bucks for a article via the internet is apparently a secret of the e-world.

[amaryl]

You are quite wrong, once published, the work is not public domain. Would you consider a novel or a textbook to be public domain after it is printed?

You are not a bad person.

I think its just play of word licensing...A license holder holds the right exclusively to let his work to be used commercially or he may sell to another party for commercialization of work...Patents.

Well licensing word should not hold for author of research paper to my knowledge...If you are letting your work print...its soon be made in to copies of journals and sold off n be in public domain.

I have no idea do authors earn money by publishing their work in journals? If they earn then its like license holder as stated by you.

Regards,

Amaryl.

[Uwe Neue]

It's not the authors, it's the journals that got to make a living one way or the other. Until a few years ago (and still today depending on the publication), the author was paying for reprints of his work, so that he could distribute it outside the distribution channel of the journal.

Most of the time, the reprint articles that you obtain from the authors are not therefore not free either. In this case it is the author who is paying, and you are getting a freebee from the author...

[Rafael Chust]

Since we are all wondering about copyright, in Portugal every copy machine pays 10% of its value to SPA (Portuguese Authors Society).

Also copy paper pays 3% of its value to the same society.

The curious thing is that SPA is filthy rich and the authors not...

Anyway, for science papers, I know Uwe is right. But the interpretation in the US is quite different then other countries... That's why Microsoft is so rich and there is no competitition from other companies in Europe - because law enforcement in the US protects Microsoft and other copyright owners.

Is it right or wrong? Depends on the side you are (if I was a kind of Bill Gates I would be living in the US for long!!!)