Polymeric and other content can contribute up to 90% of the total mass in a pharmaceutical product, where excipients play a critical role in the drug’s performance. In just one example of the importance of excipient properties for therapeutic effect, the molar mass and degree of branching in polymeric excipients directly impact the rate of drug release.

Separation Science, in collaboration with Wyatt Technology, has developed a presentation showing how conventional characterization techniques including size exclusion chromatography (SEC) and bulk viscosity measurements may fall short. The addition of light scattering analysis provides complete characterization of molar mass, viscosity, branching, conformation, conjugation, and size of excipients and other polymers.

The aims of this presentation are to...
    - Describe the principles of multi-angle light scattering (MALS) detection and calculation of polymer molecular size and mass
    - Show how to identify and overcome shortfalls of conventional GPC/SEC
    - Leverage dynamic light scattering (DLS) and viscosity for enhanced characterization of molecular size
    - Explain how to calculate copolymer ratios and molecular weights in-line with SEC
    - Outline the advantages of field flow fractionation (FFF) for separation of branched polymers

If you'd like to view the on-demand presentation you can visit the 'Light Scattering Techniques for Protein and Polymer Characterization' portal at:

This presentation is given by Dr Andrew Meyer, who joined Wyatt Technology in 2001, serving for several years as an Applications Scientist, then as Dean of Wyatt's "Light Scattering University" and as Director of Customer Service & Support. Currently, he is responsible for sales and support in Wyatt's Southeast Region, introducing Wyatt's innovative technologies there, determining which instruments best match customer requirements, and ensuring complete customer satisfaction with all of Wyatt's products throughout the region.