Since this is a forum to discuss issues and questions in chrom and mass spec, I’d like to bring your attention to a great inexpensive solution to single quad GC/MS or LC/MS users who would like to perform accurate mass formula determination – before you laugh too hard, check out Cerno Bioscience’s MassWorks software which has a VERY different take on mass spec calibration, a flash demo of which is available at

http://www.cernobioscience.com/CernoDemo.html

Users of single or triple quad LC/MS and single quad GC/MS have been able to perform impurity/degradant/flavor/fragrances formula ID and medicinal chemistry support. In the case of GC/MS with EI, it has been possible to determine the formulas of either molecular ion or fragment ions or both, even for true unknowns. See three application notes for more details:

http://www.cernobioscience.com/resource ... Search.pdf

http://www.cernobioscience.com/resource ... mental.pdf

http://www.cernobioscience.com/resource ... fusion.pdf

Contacts: info@cernobioscience.com