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TLC: plate destruction

Posted: Thu Aug 09, 2018 11:42 am
by dap
Hello.
We've tried recently Acetonitrile/Water/Ammonia 4:6:0.2 as a mobile phase with Silicagel & C18 plates both alumina by Merck. After development stationary phase unglued from alumina and alumina got black color.
Any tips please?

Re: TLC: plate destruction

Posted: Sat Aug 18, 2018 5:27 pm
by tom jupille
Aluminum is corroded at alkaline pH. Best suggestion would be to switch to glass plates (or avoid alkaline mobile phases).

Re: TLC: plate destruction

Posted: Sat Aug 18, 2018 6:00 pm
by dap
Both SiO2 & Al can be damaged by hight pH but methanol/ammonia is almost fine mobile phase.