Robustness test for Related Substance

Off-topic conversations and chit-chat.

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Can I use Change in Detector for Robustness Test? Is it okay if I'm going to use PDA detector first and changing it into 2487 UV/VIS detector? Thanks.
I would say no. Changing the detector is changing the method. Robustness should only alter the method conditions.
jayroseville58 wrote:
Can I use Change in Detector for Robustness Test? Is it okay if I'm going to use PDA detector first and changing it into 2487 UV/VIS detector? Thanks.


Of course you can! This way you will have established method robustness over both UV-detector models. Especially in the future as you might need to transfer the method to another laboratory with PDA/DAD detectors only.
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