-
- Posts: 1862
- Joined: Fri Aug 08, 2008 11:54 am
(1) Conditional sample sequences: if line 1's peak of compound A is too small, proceed to line 2 (inject more, or a more concentrated sample), otherwise skip to line 3.
(2) Calculate the inner product of an LC-MS spectrum and the same spectrum shifted X units left. Soooo useful for neutral losses. This just means take a copy of the spectrum, move it X units leftwards, multiply each intensity of ion in the region where the two spectra overlap by its corresponding value in the other unshifted spectrum, and sum all the values. If you have a peak that fragments to something X units lighter (source fragmentation), it will be intense in both the unshifted and the shifted spectrum, and you get a big signal. This really does work, and is a valuable addition to single quads, and useful in ion-traps, where it will pick up things that weren't chosen for data-dependent fragmentation.
(3) One that exists already, but ought to be universal: calculate the solvent necessary to complete the gradient.
(4) A pressure-burst "fuse" for fluorescence cells. Surely someone must be able to make something a little cheaper than a fluorescence cell that will break just before the expensive cell does? Even just a pressure-valve liquid equivalent of the safety valve on a boiler would be great.