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- Joined: Mon May 19, 2008 10:09 am
although it is a chromatography forum, I thought this could be something for around the water cooler.
We have perform water determination on an oil based pharmaceutical product. We expect about 0.25% water in the product.
We can use volumetric Karl Fisher, but it seems that this isn't recommended for such a small water content.
Coulometric Karl Fisher seems the way to go, after some searching on the web).
But if we use 5ml of our product, we have 12.5mg water to titrate. Is volumetric Karl Fisher useable in this range, or should we really use Coulometric KF?
Is there a way to justify the volumetric KF?
We found a suitability test by adding know amounts of water to the product, and then perform linearity, and check the intercept with X an Y axis, and everything was within the limits as stated in the test.
Any insights on this non chromatography stuff?
Ace