Thank you for all your replies.

Maybe I let out some information or was unclear because I´m no native english speaker.

It´s the risk assignment for the lab where I´m writing my bachelor thesis. They want to know, how much of the cancerogeneous compounds that enter the meassuring system during one run could escape in the case of a e.g. broken transferline. Therefore I have to calculate which sampling method brings in the most amount of analyte into the system. We have a limit of 1000 ppm which is the maximum concentration allowed to use. I know that this is way higher, than the concentrations needed.

But given, that I measure a 1000 ppm solution, with which sampling method do I introduce the biggest amount of analyte into the system under standard conditoins. For the liquid phase sample methods it´s easy. The calculations for SPME and SBSE are done by a colleague. But I struggle with the calculation for head space sampling.

When we have the calculated values for all used sampling methods, we will choose the one that intruduces the highest amount of analyte into the system and calculate with this amount and the volume of the lab, the possible workplace concentrations if something goes wrong. If we have this value, we can take a look at the legal limits and can than say "Well, 1000 ppm might be the maximum allowed concentration, but maybe we should only use 200 ppm solutions, because if something is broken, we exceed the legal limits."

This has to be a strictly theoretical calculation and therefore I have to calculate the amount introduced when 1 mL of head space gas is analyzed.