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HPLC VS GC

Posted: Fri Jan 27, 2017 2:51 pm
by 123jayne
How would aromatic compounds best separated?
Toluene, Benzene, nitrobenzene and acetophenone best separated GC or HPLC?

Re: HPLC VS GC

Posted: Fri Jan 27, 2017 5:22 pm
by Steve Reimer
Toluene, benzene and nitrobenzene are all target analytes for volatile organics analysis. Nitrobenzene and acetophenone are both targets for semi-volatile organics analysis. Both of those are GC (with MS detection).
All would be easily separable in HPLC with detection by UV.
So the answer is; the best one would be the one you have available. Also how certain do you need to be of identity and how low of concentration do you need to detect?