Finding LC/MS method validation guidlines

[abaarali]

Hi,

Could you please help me to find a guidelines to validate LC/MS method in our system.

Thanks

[dblux_]

Hi,

Could you please help me to find a guidelines to validate LC/MS method in our system.

Thanks

http://www.labcompliance.com/tutorial/m ... 3_standard

[abaarali]

Thanks, this is the first time I apply LC/MS in our geography department. Do you think this is only apply to LC/MS and not LC/UV. I don't know why I feel that LC/MS require more attention during validation and for this I have been looking for something specific to LC/MS. Maybe I am wrong and this report can work in both.

[dblux_]

If you determine validation parameters:
•Accuracy
•Precision
•Specificity
•Limit of detection
•Limit of quantitation
•Linearity and range
•Ruggedness
•Robustness
and they fulfil requirements for intended use than your method would be validated.

[abaarali]

Thank you very much.