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- Posts: 45
- Joined: Sat Dec 18, 2010 5:58 pm
I am analyzing Water content in Glimepiride as per USP 35 with coulometer. The limit is NMT:0.5%. I am not getting reporducible results. The results of a same sample are from 0.3 to 1.5%. Please let me know what could be the reason?
Procedure; Dissolve 0.25g of sample in 5 mL DMF previously dried over moecular seives. From this solution add 1mL into the titration vessel.
Thanks