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Why do almost no CE methods use an internal Standard

Posted: Sat Nov 21, 2015 1:00 pm
by MSCHemist
Why do so few CE methods use an ITSD? I've read quite a few and see almost none. I would think with the variability of how much material gets injected it would be very beneficial.

Re: Why do almost no CE methods use an internal Standard

Posted: Wed Nov 25, 2015 10:04 am
by DeusEx
I don't know, but i always try use an internal standard when developing a method. In CE is easy to have variations in injected volume (due to the low volume injected correlated with viscosity and superficial tension difference) and migration time due to almost omnipresent EOF.