High-Low Calibration with Inline Dilution (Metrohm IC)

Discussions about IC and related topics

7 posts Page 1 of 1
Hello,

We are trying to extend the calibration range of both our anion and cation calibrations to account for high concentration ranges in wastewater samples. We are currently running a Metrohm 940 IC with Inline Filtration and Inline Dilution.

Our current analytes of interest are as follows:
anions: F, NO2, Br, NO3, SO4, PO4
cations: Na, NH4, K, Ca, Mg

I would like to set up the high-low calibration technique as specified in the S349 Metrohm application note, but this is for Partial Loop injection, which we do not have. According to a webinar I watched delivered by Dr. Andrea Willie, I believe this technique is possible with Inline Dilution.

Can anyone confirm this for me and ideally send me any tips to set it up with Inline Dilution on MagICNet 3.1? I would be very appreciative of any assistance.
Dear alroko

High-low calibration can be applied to any calibration type the important part, that the highest calibration level of "low" is also the lowest level of "high".
As I am out of the office right know, contact Elke Suess (elke.suess@metrohm.com) for more details.

Best regards
Markus
Dr. Markus Laeubli
Manager Marketing Support IC
(retired)
Metrohm AG
9101 Herisau
Switzerland
Hello Markus,

Thank you so much! Hope all is well with you.

Cheers!
Dear Alroko

Sorry for the late answer. Yes, all is OK. After retirement, I go on with one day per week. Right now of course from home.
Dr. Markus Laeubli
Manager Marketing Support IC
(retired)
Metrohm AG
9101 Herisau
Switzerland
Dear aricjoshua

To specify:
There are two calibration curves are combined.
The connection is given by the highest level of the "low" calibration which also must be the Lowest level of the "high" calibration.
Dr. Markus Laeubli
Manager Marketing Support IC
(retired)
Metrohm AG
9101 Herisau
Switzerland
Markus Laeubli, Metrohm wrote:
Dear aricjoshua

To specify:
There are two calibration curves are combined.
The connection is given by the highest level of the "low" calibration which also must be the Lowest level of the "high" calibration.


When we were doing the two calibrations we had the "low" point of the High curve just below the "high" point of the Low curve. Example would be a Cl with Low curve 0.1,0.5,1.0,2.5,5.0 then High curve 4.0, 6.0, 8.0, 10.0 or something similar to that. It worked very well on the older model we were using at the time.
The past is there to guide us into the future, not to dwell in.
When we were doing the two calibrations we had the "low" point of the High curve just below the "high" point of the Low curve. Example would be a Cl with Low curve 0.1,0.5,1.0,2.5,5.0 then High curve 4.0, 6.0, 8.0, 10.0 or something similar to that. It worked very well on the older model we were using at the time.


Dear James_Ball

How did you decide which calibrtion to apply in the range between 4 and 5?
Dr. Markus Laeubli
Manager Marketing Support IC
(retired)
Metrohm AG
9101 Herisau
Switzerland
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