Shimadzu Prominence issue

Discussions about HPLC, CE, TLC, SFC, and other "liquid phase" separation techniques.

2 posts Page 1 of 1
I have the same problem as Mattias from Denmark had posted. Sometimes with 100% Acetonitrile in a line, the pressure varies and the mix is not OK. Our supplier and technical service changed the valves for new ones that Shimadzu recommended but didn´t solved the problem. Anyone knows why this happen?
Q. F. Ignacio Viera
I have understood that it is common that acetonitrile can make the little ball inside the check valve too "sticky". If the ball cannot move freely, than you get pressure variations.

I am now testing to use 90/10 of acetonitrile/water instead of 100% acetonitrile, and so far it seems to work. But I am not sure yet.
2 posts Page 1 of 1

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