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- Posts: 2
- Joined: Fri Nov 02, 2018 7:18 pm
The primary user of our Waters UPLC Xevo TQD was let go a while back and we have been sort of teaching ourselves how to use it. We have an ESCI+ source (ES+/- and apci +/-). We don't typically use APCI and thus don't use the corona needle. However I don't think forming droplets on it are intended and it probably indicates too much fluid is being discharged from the ESI needle. We run at 0.4 ml per minute with 10% acetonitrile to 90% acetonitrile with 0.1% formic acid. MS parameters are as follows:
Desolvation temp: 350 C
Source temp: 150 C
Desolvation gas flow: 650 L/hr
Cone gas flow: 20 L/hr
I'd prefer not to decrease flow rate as that would increase our run times. Would increasing cone or desolvation gas flow help nebulize the droplets better?
Thanks for any help.