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- Posts: 15
- Joined: Fri Aug 31, 2018 10:12 pm
I'm running two samples that include the same standard material, but one is dissolved in water and the other in methanol. I'm using LC-ICP-MS to quantify the sample (using water/MeOH mixture as the solvent, % MeOH increases gradually over time), but I get ~10x higher signal (peak area) with the standard dissolved in water than in methanol. Since I added the same amount of standard material to both samples, I was expecting to see the same intensity from both samples, and I'm trying to figure out why. On the LC part, maybe the autosampler has some issue with drawing methanol up and less sample got in? I'm not sure what could really happen on the MS part and wanted to see if anyone had some advice.