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- Posts: 6
- Joined: Tue Jan 08, 2019 12:56 pm
Some compounds aren't visible at all, we just get a noisy baseline. Some compounds do have peaks with corresponding masses but the peaks are very wide with heavy tailing. Only one compound of the ~20 references I tested came out with a nice sharp defined peak.
The method I am using is the same as prior to the repair and the same as used by another lab with their GCMS (they get nice defined peaks with the same compounds).
I am noticing a slight pattern (needs further testing to prove though) but I think the lower boiling point compounds we test generally have better peak shapes than the higher boiling point compounds.
Could it be that the interface is not heating correctly and the higher boiling compounds we test condense and don't make it to the MS?
Alternatively, perhaps our column degraded whilst the MS went off for repair. I don't know if the column was plugged whilst it was disconnected.
The system passes the tune program fine, there are no major leaks.
Any input would be appreciated. If necessary I can post the method but I really don't think that is the issue.
Thanks!