1,4-dioxane by 522 column modifications

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

2 posts Page 1 of 1
Hi all,

Has anyone attempted to use a thinner film than 1.4 um for 1,4-dioxane by EPA 522? We are setting up a new instrument (6890/5973) to run PAH by 8270 and 525. If 522 by a 1.0 um column is feasible, I'd like to give it a shot as our subcontract lab for 522 is quite slow. Otherwise we'll stick with 0.25 um and enjoy the shorter run times for 525/8270.

Thanks.
We used the Rtx-624SilMS column for 522 for 1,4-Dioxane. You may be able to see it with a thin film 5 phase column but I think it will be difficult to separate it from the solvent peak, you need a phase a little more polar to retain it. The newer method EPA541 uses a Wax column for 1,4-Dioxane and other alcohols and works well.

I would say give it a shot and see what happens, can't damage the column and the standards are not expensive. You will need to start with the oven temperature as low as possible I think though.
The past is there to guide us into the future, not to dwell in.
2 posts Page 1 of 1

Who is online

In total there are 10 users online :: 0 registered, 0 hidden and 10 guests (based on users active over the past 5 minutes)
Most users ever online was 599 on Tue Sep 18, 2018 9:27 am

Users browsing this forum: No registered users and 10 guests

Latest Blog Posts from Separation Science

Separation Science offers free learning from the experts covering methods, applications, webinars, eSeminars, videos, tutorials for users of liquid chromatography, gas chromatography, mass spectrometry, sample preparation and related analytical techniques.

Subscribe to our eNewsletter with daily, weekly or monthly updates: Food, Environmental, (Bio)Pharmaceutical, Bioclinical, Liquid Chromatography, Gas Chromatography and Mass Spectrometry.

Liquid Chromatography

Gas Chromatography

Mass Spectrometry