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Does anyone have any tips as to what is simplest and most reliable?
Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.
MSCHemist wrote:
The GC-thermal energy analyzer looks interesting but I am not looking to buy a new GC instrument for this. I only found one or two companies that make it.
The SPE also looks ok, the only trouble is I don't have a vacuum manifold for SPE and I notice they acidify the samples before putting them on the column. At least one of the papers reported that nitrosamines are not stable in acidic solutions.
It looks like a headache. I tried doing GC/MS of acrylamide a while back and it was too dificult to extract unique ions for native acrylamide, and I got closer with derivatization with xanthydrol I still had matrix cleanup issues. The only derivitization I found for nitrosamines involves denitrososifying with hydrobromic acid and I really don't want to get into that. This is a job for GC/MS/MS, chemical ionization or TEA.
I may try SPME or suggest they go contract lab for this.
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