I am looking to develop an SLE method on some biological solutions such as human plasma. And one of the conditions I am checking for is how much Lysophospholipid breaks through the SLE plate. All the literature that I am finding so far seems to be quoting LC-MS/MS.

However, all I have available in the lab I work in currently is a HPLC-UV (and a GC-FID but that isn't going to be used for this task) and soon we will have an LC-MS. I know with the PDA it won't pick them up without adding on a fluorenscent molecule to mark the compound so I ruled that one out for now. But is there any reason I can't use an LC-MS with just a single quadrapole. I can't see to find much literature quoting why you need a triple quadrapole to detect lysophospholipids in a sample. Is it just you don't get the best sensitivity or signal to noise? I don't need to identify exactly the isomer, just the presence and/or lack of them in the solution being injected onto the LC.