Several points to consider:
1. The separation per se is a function of the column and mobile phase chemistry. Coupling a MS to an IC system will affect detection.
2. The use of MS for detection imposes some serious constraints on what mobile phases you can use. Specifically, all components of the mobile phase (including buffers!) must be reasonably volatile.
3. "IC" is really just a subset of LC (generally, using conductivity detection). In principle, coupling a mass spec to an IC system is exactly the same as coupling it to an LC. The devil is in the details: MS detection generally requires flow rates that are low (and correspondingly small columns) by IC standards. If your system can handle the flow rates, and has sufficiently small extra-column volume, then it should work, but it probably won't be "plug and play"!