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- Posts: 5
- Joined: Thu Sep 02, 2004 12:56 am
I am seeing gradual response drop when injecting same extracted sample (protein precipitation) for ESI+ analysis. After the system was idle for some time, the response came back but dropped again with injections. Is this mainly due to matrix effect on my column or matrix effect on the ionization process or something else? How to solve the problem? Any suggestion is appreciated.
Regards
Linda