Hello, It´s nice to find a chrom- forum so good...thanks for maintain it...
I´d like you to answer a theoretical question about MS quadrupole detectors: I know that simonizing MS detector is the way of calibrating it, and that each time I do “Autotune”, I`m changing the voltages of lenses and that´s the main cause of doing parametrical calibration each time (constructing a regression curve).
At work, they have ask me to make a study of intervals of regression function for each analyte in order to enclose an interval of good performance for linear term and constant.
In my opinion, that´s not possible for MS detectors, but I need to demonstrate it and to provide evidences or written documents, such as books or papers (signed for someone more famous than me :D ) that make me able to prove it.

Thank you very much,