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Base peak chromatogram vs TIC
Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.
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I get confused while trying to understand the difference between Base peak chromatogram, TIC and selected ion current profile (mass chromatogram). And I cannot see what is, in practice, the difference in information provided by the different graph. Any help will be greatly appreciated.
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The BPC shows only the signal from the most intense mass in any given mass spectrum, plotted versus time. The TIC shows the sum of the signals from all masses in any given spectrum, plotted versus time. Selected ion current or extracted ion chromatogram (EIC or XIC) shows the signal from a single mass selected by the user, whether or not that mass is the most intense at any given time.
The BPC will often look similar to the TIC, but less noisy. However, chromatographic peaks consisting of signal at many masses can be understated by the BPC.
The BPC will often look similar to the TIC, but less noisy. However, chromatographic peaks consisting of signal at many masses can be understated by the BPC.
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Thank you to all. It is clear now.
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