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Low mass cut of in CID experiment

http://www.chromforum.org/viewtopic.php?f=3&t=1953

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Low mass cut of in CID experiment

Posted: Sun May 15, 2005 9:25 pm
by Ricardinio
Can any one explain why the low mass cut off in CID experiment is about 1/3 of the precursor ion? Thanking you before hand.

Posted: Mon May 16, 2005 2:09 pm
by MG
Well, whether you are doing scan or MS/MS on an ion trap, the low mass cutoff can usually be set by the user. I do not know the mathematical reason why 1/3 is a good value. However, I can tell you that the low mass cutoff is not a sharp boundary between stable and unstable masses. For example, m/z 100 will be transmitted more efficiently with the cutoff set to 50 rather than 60 (at least with the ion traps I've used).
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