By Anonymous on Monday, June 21, 2004 - 03:25 am:

Hello, I am looking for general informatin about hplc/ms and hplc/ms/ms. i would like to write a short info-paper about this technics... pls if you can send me some links or some documents which i can use I will be appreciate mjb142@wp.pl

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By Anonymous on Wednesday, June 23, 2004 - 03:26 am:

Dear Anonymous (mjb142),

This website may give a clear picture in LCMS.

http://www.forumsci.co.il/HPLC/program.html

Have a nice reading...

Siva

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By jack on Wednesday, July 14, 2004 - 07:24 pm:

is anyone have some idea to extract streptomycin in honey matrix and then run on lc/ms/ms, please help

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By Anonymous on Monday, December 30, 2002 - 02:08 am:

hi folks,
i am new to LC-MS and wish to buy a LC-MS system for my lab to do impurity profiling and charecterization ( Drugs and peptides ), can u pls let me know about the best and worst instruments available for this kind of job and kind of mass detector required. i also wish to know whether LC-MS is sufficient ot LC-MS-MS.

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By L.Kalyanaraman on Tuesday, December 31, 2002 - 04:05 am:

For Impurity profiling LCMSMS will be an ideal machine. The advantage of LCMSMS over LCMS is the additional fragmentation information which is vital for structure elucidation along with other technique like NMR.

Quadrupole mass spectrometers will serve your purpose. But a QTRAP (Quadrupole combine with a Iontrap detector) will be more suitable for your work. Excellent machines are available with Applied biosystems and Waters Micromass.

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By Anonymous on Tuesday, December 31, 2002 - 06:32 am:

What you need to do is invest in a book and do some reading. The following title outlines very nicely the pros and cons of each style of MS and the uses they are best suited for.

A Global View of Lc/MS: How to Solve Your Most Challenging Analytical Problems -- by Ross Willoughby, et al; Paperback
Buy new: $49.95 @ Amazon.com

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By Anonymous on Tuesday, February 25, 2003 - 01:01 am:

What kind of ionization source is more suitable for analysis of common drugs? APCI or ESI?
Thank you

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By Anonymous on Thursday, March 13, 2003 - 10:10 pm:

My laboratory wants to buy an LC/MS/MS system. The question is: for analytical and structural analysis purposes, what m/z range is optimal? I saw at Micromass and at Applied Biosystems m/z range 2-1800, and at Agilent m/z range 50-2200. Is-there an disadvantage for Agilent system?
Regards

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By Anonymous on Friday, March 14, 2003 - 06:57 am:

The range depends on what you want to analyze. If you are looking for most pharmaceutical compounds or pesticides, you will seldom look outside of the range of 100-600.
As for the disadvantange of Agilent, I have never used their MS/MS systems, but I have used their single quads, and they are not very reliable. The newer ones seem to be worse than the older ones. (We brought in a plastic lemon and placed in on whichever of the two new instruments was broken that week.) I had such a bad experience with the last one, that I would never recommend purchasing one. Micromass, Sciex, and Finnegan all produce good triple quads. I have never used Applied Biosystems.

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By Beppe on Friday, March 14, 2003 - 07:53 am:

Some clarifications :
- MS/MS can be done on to kinds of instruments : triple quad and ion trap; Finnigan have both, Agilent only ion trap, Micromass (now Waters) and Applied Biosystems have triple quad, unsure if they have ion trap.
- Applied Biosystem MS are those manufactured by Sciex
- I work with an Agilent simple quad that never caused me a serious problem.

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By Anonymous on Wednesday, April 16, 2003 - 03:56 am:

Ms/MS is more suited for your application. Personally I have worked on Micromass Triple Quad Machine and have served my purpose.

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By M.Steel on Monday, May 12, 2003 - 11:28 am:

If you are still looking, we are selling our ThermoFinnigan LCQ DECA XP LC/MS/MS at an excellent price. It was originally purchased in 2001. www.mckscientific.com

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By Anonymous on Thursday, June 5, 2003 - 02:05 pm:

I found this course which offers a loads of information on LC/MS systems: Applying LC-MS to
Pharmaceutical Analysis.

http://www.pti-international.com/LC-MS/

Hope you all found this site helpful!

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By Anonymous on Thursday, June 26, 2003 - 04:28 am:

Are there any LC-MS courses in Europe?

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By Tomasz on Thursday, July 31, 2003 - 02:52 am:

Hello,
I want to buy an MS analyzer for structural analyses (structural elucidation) of organic compounds, unknown drugs metabolites and quantification of pharmaceuticals in serum. A local sale agent of a MS manufacturer told me that their single quad instrument can satisfy these needs due of CID phenomena, which is responsible by some in source fragmentation of compounds. I have seen some MS “spectraâ€