LC/MS nitrogen generator maintenance and alternatives

Discussions about GC-MS, LC-MS, LC-FTIR, and other "coupled" analytical techniques.

8 posts Page 1 of 1
We have an Agilent LC/MS that runs off a Parker Nitroflow Lab nitrogen generator. About three years ago, the cost of changing the two compressors was of about $4,500 USD and this year it seems to have jumped to $7,500 which really ups the cost of running and maintaining the generator, especially given we are an academic institution with very limited funding. When we originally got the system, we were under the impression that it would be a lot cheaper this way, especially since Parker states that the total cost for a year is like $890 in some of their brochures (https://www.parker.com/Literature/Gas%2 ... _Paper.pdf).

So people with limited cash, how do you approach the nitrogen generator issue? $7,500 every year might just be more than we can afford depending on the year. This number is the service itself, but when I asked Parker to quote me for the individual parts, the two compressors came up to more than $10k!
The price of operating generators depends on whether you've got good compressed air already in the building. If you do, and it's of a sufficiently high pressure, you don't need a generator with built-in compressors, and it's the built-in compressors that fail. The rest of the generator will run with little maintenance for a long time. In fact it'll work even better if it's not attached to a hot and vibrating compressor.

If you've only got one instrument, there isn't much alternative, and all the generator manufacturers will fleece you for outrageous sums for replacement little compressors, which will fail depressingly regularly.

If you have the space, you can get a generator that uses an external compressor, and find your own compressor. If you are a larger lab or technical platform with multiple instruments and a higher demand for nitrogen, abandon the mini-generators and get a big system with a separate compressor. This is much more efficient and much less liable to failure; we're using a big generator capable of over 200L/min with a variable-speed screw compressor producing 10-bar air to feed it, and after some initial hitches that have been ironed out, it seems (looking around for wood to touch) to be pretty good. Although it looks alarming, it was also cost-effective to purchase, compared to a whole suite of little 30L/min generators. Of course when it fails, the entire lab stops...
Talk with Gas Generator Solutions. They will rebuild the compressors. We keep a spare set of compressors from a previous PM to send out for refurb and have them swap out when the PM is performed.
lmh wrote:
The price of operating generators depends on whether you've got good compressed air already in the building. If you do, and it's of a sufficiently high pressure, you don't need a generator with built-in compressors, and it's the built-in compressors that fail. The rest of the generator will run with little maintenance for a long time. In fact it'll work even better if it's not attached to a hot and vibrating compressor.

If you've only got one instrument, there isn't much alternative, and all the generator manufacturers will fleece you for outrageous sums for replacement little compressors, which will fail depressingly regularly.

If you have the space, you can get a generator that uses an external compressor, and find your own compressor. If you are a larger lab or technical platform with multiple instruments and a higher demand for nitrogen, abandon the mini-generators and get a big system with a separate compressor. This is much more efficient and much less liable to failure; we're using a big generator capable of over 200L/min with a variable-speed screw compressor producing 10-bar air to feed it, and after some initial hitches that have been ironed out, it seems (looking around for wood to touch) to be pretty good. Although it looks alarming, it was also cost-effective to purchase, compared to a whole suite of little 30L/min generators. Of course when it fails, the entire lab stops...


This is what we switched to using. We have one of the Nitroflow units that run off the in house air system. We upgraded our building wide compressor to a huge dual stage one, but for just a single LCMS I would think that the smaller dual stage that can be found at Lowe's or similar hardware supplier would work well. Definitely get the dual stage, they cost a little more, but the increased capacity and pressure work well to prevent the compressor from running constantly. Dual stage will have oil in them, but that can be filtered out. We bought a system that reduces both oil and moisture in the system, it is a refrigerated condensing unit which gives us a constant supply of dry air for the building. I believe it is a Campbell Hausfeld unit, they are available at places you will find commercial grade air tools.

The biggest maintenance item it to remember to vent/drain the condensed moisture and oil from the bottom of the air compressor tank at least weekly, if not daily. This reduces the load on the initial filters and prolongs the life of the compressor. Oil changes in the compressor are usually requires twice a year. Otherwise the Nitroflow just need maintenance every few years if you keep it fed with clean air.
The past is there to guide us into the future, not to dwell in.
We are using a PEAK N2 generator. There is a water drain line, and usually fill up the waste water tank quickly. However, recently, we don't see any water coming out of that drain line, does that mean something wrong, and what needs to be fixed ?
It could be a stuck valve or float on an automatic water separator or condensate drain. Usually there are multiple in a unit. It only takes about 30 minutes to check them all to be sure they are draining.

Also, the amount of condensate water collected is proportional to the humidity in the ambient air. We collect about 3-4x the volume of water in the summer as in the winter.
Using the refrigerated dryer I mentioned above, we never see any moisture in the traps anymore. Our first unit lasted over 15 years, well worth it over time if you need air for multiple uses in the lab.
The past is there to guide us into the future, not to dwell in.
Buy directly from compressor company. Not sure about your specific model, but mine was under 1500 USD for 2 compressors.
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