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- Posts: 68
- Joined: Wed Mar 25, 2020 8:52 am
When running a new sample matrix what type of precations do you take to prevent contamination? LC QqQ instrument.
Obviously I would start a dilution series to investigate signal. Would you run full ES+ and ES- to check background in addition to target analyte mass? Also remove particles by spinning 10 000 rcf or filtering of sample 0.22um.
My fear is that I have crap that i wont see at high conc if I just scan for target analyte and will contaminate instrument with matrix. So what do you suggest for a new unknown sample, any general recommendations!