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- Posts: 12
- Joined: Tue Jun 08, 2021 8:13 am
for the next years I am plannig to analyse the headspace of many samples by SPME-GC/MS (PerkinElmer SQ8). For about twenty targets we would like to perform relative quantifications (I measure only the peak areas and compare them among the samples).
We will receive the samples in bunches during the next few years, and they have to be measured shortly after we have received them. Therefore, the GC/MS will be re-tuned, switched off, cleaned etc. all along these measurements. This will produce sensitivity fluctuations of the mass spectrometer.
Do you think using an internal standard (4-heptanone or 1,2-dichlorobenzene) for data normalization is enough to take the fluctuations into account?
What is your experience with such fluctuations? How do you deal with it?
Many thanks for your advice in advance!
Kind regards
Christian