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- Posts: 11
- Joined: Fri Apr 09, 2021 6:18 pm
We are using in our lab a Thermo GC-MS, with Xcalibur software (quite a little bit old model).
We are validating a method and we have to calculate the Limit of Detection (LOD). I'm supposed to inject ten times a reagent blank and see how much the noise signal is, in order to get the signal where S/N equals or exceeds 3.
Here goes my question: How can I proceed to know the noise at my retention time of interest? (apparently, the Rt where my analite would elute, isn't it?). I have been seeking and the only thing I've found is an option where peaks are labelled with, for example, "17 SN RMS". However, reading the Help guide I've understood that noise is expressed as RMS. But I thought SN meant Signal to Noise ratio. I quite don't understand it, and the Help guide is not too helpful with my queries.
COuld you help me find the light with this?
Thank you very much
Laura