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- Posts: 148
- Joined: Wed Jul 03, 2013 1:51 am
- Location: Michigan, USA
However, we have begun noticing that the calibration curves for nearly all substances, negative and positive mode, are now upward-facing quadratics rather than nice straight lines as they were before. We have noticed this effect at the prescribed 1 mL/L (5uM) dosing but also even at 100 uL/L (500nM). This indicates ion suppression imo.
Has anyone else had experiences with medronic acid additives to the mobile phase - positive or negative? I would be curious.