-
- Posts: 3
- Joined: Thu Sep 23, 2010 9:06 pm
We're in the process of purchasing a new UPLC/MS system, and I'd really appreciate some feedback from anyone who has experience with kit from either of the two vendors. Our two choices are:
- Thermo Vanquish Core/ISQ-EC with Chromeleon 7.2
or
- Agilent 1260 Infinity II Prime/MSD iQ with Openlabs CDS
Both HPLC's are similarly spec'd and priced, with the principal difference being the pump (Vanquish binary/700 bar; 1260: quaternary 800 bar).
Both mass detectors have similar performance specifications, with the ISQ having a HESI source, the iQ an ESI source. The footprint for the iQ is much smaller, has a smaller rough pump, lower gas flow requirements. The ISQ appears to be an evolution of the MSQ+. Greater mass range for the iQ, slightly slower scan speed. Mass stability is better for the ISQ over the iQ (0.1 Da over 48 hours vs 12 hours for the iQ). Sensitivity is comparable.
Really interested in hearing peoples experiences as to the robustness of the two systems, technical support etc.
Note that we currently use several Summit systems (DAD and ELSD) and an Agilent 1100 (VWD/FLD). I've come from an Agilent ecosystem and have always been impressed as to their reliability, though the iQ is new and a bit of an unknown. Whilst of a similar vintage to the 1100, the Summit systems have caused me no end of problems. Our intended use is primarily for high throughput analysis of chemical markers in honey, though we'll look to swing the analytical hammer at whatever we can.
Thanks, Matt