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- Posts: 148
- Joined: Wed Jul 03, 2013 1:51 am
- Location: Michigan, USA
we have a puzzling situation here on our GCMS. We inject a Grob mix to test system suitability. We decided to switch the solvent from ethyl acetate to acetonitrile and to double the concentration of the analytes.
Surprisingly, we see a decrease in MS-Signal for all analytes across the board when we make injections of both solutions. I.e. there is about 1/2 the signal for the ACN injeciton despite it being twice as concentrated.
Peak shapes are good in both cases and are actually improved a little with ACN.
Any ideas how this could be explained? Thank you!
Injection parameters: 250°C, Split: 1:25, Inj. Vol: 1 µL, Column flow: 1.25 mL/min, Pressure: 10 kPA, Liner: 3.5mm.