bunnahabhain wrote:
Maybe your matrix changes over the years?
Matrix effects originate from co-eluting substances which facilitate or quench the ionization process of your target molecule.
I my be wrong, but I think as long as your standard performs as expected, replacement or cleaning of hardware is not required.
Thank you very much for your time and reply, bunnahabhain.
We have liver and urine samples, so.. matrix changes over the years is not impossible (feeding products and protocols in the market do change over time) but we do not believe it to be the most likely source of the problem.
We have seen, since equipment was new, a slow change into less sensitivity / greater matrix effect in injections.
We strongly believe there is equipment parts erosion behind this effect, but we battle about what it might be.
Any thoughts?
Thanks