rb6banjo wrote:
Interesting approach by Restek. This is the first I've heard of it. Thanks for the tip.
In my hands, SPME has been great for quantitation. I use it all the time. I will say that I think it really shines when you're looking for small concentrations of analytes. That's the "lions share" of what I do. I generally make sure I'm calibrating in the matrix because what else is present, can have a huge impact on how the analytes partition into the coatings.
I've had more difficulty when I'm trying to quantitate things present at percent-type concentrations. I will always go a different way for those kinds of things.
At percent levels I would either do dilute and shoot or headspace with high split. SPME and Purge and Trap are normally for trace analysis using the adsorbents to concentrate the sample.
I can see these blades working where you have analytes without many interfering signals but with a lot of physical matrix to eliminate, especially something like a soil sample. Not sure how well it would work for something like pesticides in Hemp, because there was always so much noise in the baseline on those samples from co-extracted analytes, if not separating it with LC you would need very high mass resolution to identify true positives.